Read the paper at New England Journal of Medicine

Words from Dr. Mario Nucci

“Electroconvulsive Therapy has long been considered the gold standard for Treament-Resistant Depression. In a study published on May 24th, 2023, funded by the Patient-Centered Outcomes Research Institute, evidence suggests that Ketamine Assisted Psychotherapy proves to be non-inferior in comparison to ECT for Treatment Resistant Depression. KAP is also shown not to carry the same memory-affecting side effects that come with ECT.”


Anand A, Mathew SJ, Sanacora G, et al. Ketamine versus ECT for Nonpsychotic Treatment‐Resistant Major Depression. N Engl J Med. DOI: 10.1056/NEJMoa2302399.

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